Updated Septemby Erik Petrovich: After a short wait, The Binding of Isaac: Repentance mods now work with the latest DLC. For those don't have Repentance, most mods should work completely fine. The Steam Workshop is the best place to download the best Isaac mods, but if players have the most recent DLC Repentance installed, they may need to wait for a patch or downgrade to Afterbirth to make many of these mods functional.
The best way to refresh The Binding of Isaac for long-time players is to consider using mods. RELATED: Binding Of Isaac: Top New Trinkets In Repentance Still, even with its multitude of items from DLC and the numerous new mechanics introduced with each major update, the game can start to feel stale after a certain point. The Binding of Isaac is one of the most infinitely replayable games ever made.